THE INFLUENCE OF SECRETOME THERAPY ON ERECTILE DYSFUNCTION AND D-DIMER LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Abstract
Introduction: The study aimed to determine the therapeutic effect of adipose-derived mesenchymal stem cell (MSC)-derived secretome on erectile function and D-dimer level, a biomarker for vascular health in T2DM men.
Methods: An RCT performed on men aged 40 to 70 years with both T2DM and ED. The subjects were randomly allocated to receive secretome or placebo. Erectile function was measured by the International Index of Erectile Function (IIEF) questionnaire. They also had D-dimer levels measured before and after the intervention (ie, at 12 weeks). The primary analysis investigated differences in change of IIEF scores and D-dimer levels between groups using statistical tests. Moreover, we calculated a Pearson correlation coefficient to examine the relationship of both outcomes.
Results: IIEF scores in the treatment group rose a mean of 3.06 points, compared to only half that amount with an increase of 0.5 points observed for control groups (p This difference was significant according to t-test (t = 6.72, p = 1.92e-07). The treatment group also experienced a more substantial decrease in D-dimer levels (-0.32 µg/mL on average) compared with the control group (an average change of -0.09 ug/ml), with a t-test statistic being-6.41(p = 4.44e−07). A minimal and not statistically significant correlation was also observed between improvements in IIEF scores with changes D-dimer levels (correlation coefficient: -0.11, p = 0.69).
Conclusion : secretome therapy has demonstrated a significant increase in erectile function and reduction of D-dimer levels among patients with type 2 diabetes mellitus.
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REFERENCES
Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, et al. Pathophysiology of type 2 diabetes mellitus. Vol. 21, International Journal of Molecular Sciences. MDPI AG; 2020. p. 1–34.
Syamsurizal S. Type-2 Diabetes Mellitus of Degenerative Disease. Bioscience. 2018 Mar 30;2(1):34.
Liu MC, Chang ML, Wang YC, Chen WH, Wu CC, Yeh S Der. Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction. Vol. 9, Cells. NLM (Medline); 2020.
Campbell JD, Milenkovic U, Usta MF, Albersen M, Bivalacqua TJ. The good, bad, and the ugly of regenerative therapies for erectile dysfunction. Vol. 9, Translational Andrology and Urology. AME Publishing Company; 2020. p. S252–61.
Li H, Chen S, Wang S, Yang S, Cao W, Liu S, et al. Elevated D-dimer and Adverse In-hospital Outcomes in COVID-19 Patients and Synergism with Hyperglycemia. Infect Drug Resist. 2022;15:3683–91.
Planat-Benard V, Varin A, Casteilla L. MSCs and Inflammatory Cells Crosstalk in Regenerative Medicine: Concerted Actions for Optimized Resolution Driven by Energy Metabolism. Vol. 12, Frontiers in Immunology. Frontiers Media S.A.; 2021.
Yang G, Fan X, Liu Y, Jie P, Mazhar M, Liu Y, et al. Immunomodulatory Mechanisms and Therapeutic Potential of Mesenchymal Stem Cells. Vol. 19, Stem Cell Reviews and Reports. Springer; 2023. p. 1214–31.
Chang C, Yan J, Yao Z, Zhang C, Li X, Mao HQ. Effects of Mesenchymal Stem Cell-Derived Paracrine Signals and Their Delivery Strategies. Vol. 10, Advanced Healthcare Materials. John Wiley and Sons Inc; 2021.
Feng H, Liu Q, Deng Z, Li H, Zhang H, Song J, et al. Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis. Stem Cell Res Ther. 2022 Dec 1;13(1).
Wang CM, Wu BR, Xiang P, Xiao J, Hu XC. Management of male erectile dysfunction: From the past to the future. Vol. 14, Frontiers in Endocrinology. Frontiers Media S.A.; 2023.
Nasif WA, El-Moursy Ali AS, Hasan Mukhtar M, Alhuzali AMH, Yahya Alnashri YA, Ahmed Gadah ZI, et al. Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review. Vol. 2022, Anemia. Hindawi Limited; 2022.
Siregar S, Novesar AR, Mustafa A. Application of Stem Cell in Human Erectile Dysfunction – A Systematic Review. Vol. 14, Research and Reports in Urology. Dove Medical Press Ltd; 2022. p. 379–88.
Trzyna A, Banaś-Ząbczyk A. Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy.” Vol. 11, Biomolecules. MDPI AG; 2021.
Li K, Li R, Zhao Z, Feng C, Liu S, Fu Q. Therapeutic potential of mesenchymal stem cell-derived exosomal miR-296-5p and miR-337-3p in age-related erectile dysfunction via regulating PTEN/PI3K/AKT pathway. Biomedicine and Pharmacotherapy. 2023 Nov 1;167.
Dharma Lindarto, Ginting F. D-Dimer Levels of COVID-19 patients with Diabetes Mellitus: a Retrospective study. Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI). 2023 Jul 8;5(2):55–63.
von Schwarz ER, Busse N, Angelus KM, Omair A, von Schwarz AA, Bogaardt PC. Intracavernous injection of stem cell-derived bioactive molecules for erectile dysfunction—a pilot phase non-randomized controlled trial. J Mens Health. 2021;17(4):99–108.
Wang B, Gao W, Zheng MY, Lin G, Lue TF. Recent advances in stem cell therapy for erectile dysfunction: a narrative review. Vol. 23, Expert Opinion on Biological Therapy. Taylor and Francis Ltd.; 2023. p. 565–73.
Sun DZ, Abelson B, Babbar P, Damaser MS. Harnessing the mesenchymal stem cell secretome for regenerative urology. Vol. 16, Nature Reviews Urology. Nature Publishing Group; 2019. p. 363–75.
Yorike D, Kurniawan MR, Syafaat M. Analysis of D-Dimer Level and Prothombin Time (PT) Activated Prothombin Thromboplastin (APTT) on Heparin Administration to COVID-19 Patients. Indonesian Journal of Medical Laboratory Science and Technology. 2022 Apr 28;4(1):91–8.
Wang B, Gao W, Zheng MY, Lin G, Lue TF. Recent advances in stem cell therapy for erectile dysfunction: a narrative review. Vol. 23, Expert Opinion on Biological Therapy. Taylor and Francis Ltd.; 2023. p. 565–73.
Bonanni M, Rehak L, Massaro G, Benedetto D, Matteucci A, Russo G, et al. Autologous Immune Cell-Based Regenerative Therapies to Treat Vasculogenic Erectile Dysfunction: Is the Immuno-Centric Revolution Ready for the Prime Time? Vol. 10, Biomedicines. MDPI; 2022.
DOI: https://doi.org/10.26618/aimj.v7i2.15635
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