KEGUNAAN GINKGO BILOBA UNTUK PENGOBATAN PENYAKIT NEUROLOGIS

Muftia Jauristika Sarifuddin, Nurul Annisa

Abstract


Ginkgo Biloba adalah Salah satu tanaman yang tergolong sebagai fitofarmaka atau obat-obatan yang berasal dari tanaman ialah Ginkgo biloba Tanaman G.biloba (Gb) termasuk dalam familia Ginkgoceae. Di dalam ekstrak G.biloba terdapat antioksidan, antivirus, antiinflamasi, dan juga antikarsinogenik. Dan juga telah dinyatakan bahwa ekstrak G.biloba mempunyai efek yang baik terhadap fungsi SSP (sistem saraf pusat). Untuk mengetahui manfaat G.biloba dalam penanganan gangguan neurologis. Dibuat dengan menggunakan metode studi pustaka untuk mengumpulkan referensi yang valid mengenai tanaman Ginkgo Biloba yang dapat digunakan sebagai penanganan gangguan Neurologi. Hasil literature reviewberdasarkan studi pustaka yang dilakukan menunujukkan bahwa tanaman Ginkgo Biloba yang dapat digunakan sebagai penanganan penyakit neuorologis dengan kandungan dan efek terhadap tubuh. Dalam literature review ini didapatkan tanaman  Ginkgo Biloba yang dapat digunakan sebagai penanganan gangguan neurologis


Keywords


Ginkgo Biloba, Sistem Saraf Pusat, Neurologis

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References


Gunay NE. Ginkgo biloba extract as an antioxidant in nerveregeneration. Elsevier 2020.

Margitta Dziwenka, Robert W. Coppock pp. Nutraceuticals Efficacy, Safety and Toxicity. Chapter 49 – Ginkgo biloba 681_691. Academic Press, San Diego, CA,USA; 2016.

Wang L, Zhang T, Bai K. [System evaluation on Ginkgo biloba extract in the treatment of acute cerebral infarction]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015;40(10):1096–1102. Chinese.

Chao R, Yin P, Ren N, Zhe W, Wang J, Zhang C, Wei G, Geng D, Wang X (2018) Cerebrospinal fluid-stem cell interactions may pave the path for cell-based therapy in neurological diseases. Stem Cell Res Ther 9:66-76.

Zhang DL, Li D, Wang MJ (2018) Mechanism and application of stem cell transplantation in the treatment of ischemic stroke. Zhongguo Zuzhi Gongcheng Yanjiu 22:5393-5398

Homann B, Plaschg A, Grundner M, et al. The impact of neurological disorders on the risk for falls in the community dwelling elderly: a c ase-controlled study. BMJ Open. 2013;3:e003367.

von Boetticher A. Ginkgo biloba extract in the treatment of tinnitus: a systematic review. Neuropsychiatr Dis Treat. 2011;7:441–447.

Hamann KF. Ginkgo-Spezialextrakt bei Schwindel. Ein systematischer Review randomisierter, doppelblinder, placebokontrollierter klinischer Prüfungen [Special Ginkgo extract in cases of vertigo: a systematic review of randomised, double-blind, placebo-controlled clinical examination]. HNO. 2007;55:258–263. German.

Yamasoba T, Lin FR, Someya S, Kashio A, Sakamoto T, Kondo K. Current concepts in age-related hearing loss: epidemiology and mechanistic pathways. Hear Res. 2013;303:30–38.

Lang F, Hoerr R, Noeldner M, Koch E. Ginkgo biloba extract EGb 761®: from an ancient Asian plant to a modern European herbal medicinal product. In: Wagner H, Ulrich-Merzenich G, editors. Evidence and Rational Based Research on Chinese Drugs. Wien: Springer; 2013:431–470.

Toledo JB, Arnold SE, Raible K, et al. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre. Brain. 2013;136:2697–2706.

Eckert A, Keil U, Scherping I, Hauptmann S, Müller WE. Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761. Ann N Y Acad Sci. 2005;1056:474–485.

Luo Y, Smith JV, Paramasivam V, et al. Inhibition of amyloid-β aggregation and caspase-3 activation by the Ginkgo biloba extract EGb 761. Proc Natl Acad Sci U S A. 2002;99:12197–12202.

Massieu L, Morán J, Christen Y. Effect of Ginkgo biloba (EGb 761) on staurosporine-induced neuronal death and caspase activity in cortical cultured neurons. Brain Res. 2004;1002:76–85.

Schindowski K, Leutner S, Kressmann S, Eckert A, Müller WE. Age-related increase of oxidative stress-induced apoptosis in mice. Prevention by Ginkgo biloba extract (EGb 761). J Neural Transm. 2001;108:969–978.

Yang TH, Young YH, Liu SH. EGb 761 (Ginkgo biloba) protects cochlear hair cells against ototoxicity induced by gentamicin via reducing reactive oxygen species and nitric oxide-related apoptosis. J Nutr Biochem. 2011;22:886–894.

Makary CA, Shin J, Kujawa SG, Liberman MC, Merchant SN. Age-related primary cochlear neuronal degeneration in human temporal bones. J Assoc Res Otolaryngol. 2011;12:711–717.

Walther LE, Westhofen M. Presbyvertigo – aging of otoconia and vestibular sensory cells. J Vestib Res. 2007;17:89–92.

Woelk H, Arnoldt KH, Kieser M, Hoerr R. Ginkgo biloba special extract EGb 761® in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial. J Psychiatr Res. 2007;41:472–480.

Jezova D, Duncko R, Lassanova M, Kriska M, Moncek F. Reduction of rise in blood pressure and cortisol release during stress by Ginkgo biloba extract (EGb

Rainer S, et all. Ginkgo biloba extract EGb 761® alleviates neurosensory symptoms in patients with dementia: a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials. Dovepress. 2018

Battistin L, Cagnin A. Vascular cognitive disorder. A biological and clinical overview. Neurochem Res. 2010;35(12):1933–1938.

Weinmann S, Roll S, Schwarzbach C, Vauth C, Willich SN. Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr. 2010;10:14.

Amieva H, Meillon C, Helmer C, Barberger-Gateau P, Dartigues JF. Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study. PLoS One. 2013;8(1):e52755.

Brondino N, De Silvestri A, Re S, et al. A systematic review and meta-analysis of Ginkgo biloba in neuropsychiatric disorders: from ancient tradition to modern-day medicine. Evid Based Complement Alternat Med. 2013;2013:915691.

Yang G, Wang Y, Sun J, Zhang K, Liu J. Ginkgo biloba for mild cognitive impairment and alzheimer’s disease a systematic review and meta-analysis of randomized controlled trials. Curr Top Med Chem. 2016;16(5):520–528

Birks J, Grimley Evans J. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev. 2009;(1):CD003120.

Oskouei DS, Rikhtegar R, Hashemilar M, et al. The effect of Ginkgo biloba on functional outcome of patients with acute ischemic stroke: a double-blind, placebo-controlled, randomized clinical trial. J Stroke Cerebrovasc Dis. 2013;22(8):e557–e563.

Wang L, Zhang T, Bai K. [System evaluation on Ginkgo biloba extract in the treatment of acute cerebral infarction]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015;40(10):1096–1102. Chinese.




DOI: https://doi.org/10.26618/aimj.v3i1.4155

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